The Role of Tc-99m DTPA Renal Dynamic Scintigraphy in Retroperitoneal Liposarcoma.

Abstract

PURPOSE:

Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been reported.

METHODS:

We retrospectively reviewed 7 patients with histopathologically confirmed retroperitoneal liposarcoma who underwent Tc-99m DTPA renal dynamic scintigraphy. The clinical data, histopathological findings, Glomerular Filtration Rate (GFR), and Tc-99m DTPA uptake were recorded.

RESULTS:

Dedifferentiated liposarcoma and well-differentiated liposarcoma showed dissimilar degrees of Tc-99m DTPA uptake, an observation that correlated with Ki-67 expression (p < 0.01). 4 of the 7 patients were diagnosed with dedifferentiated liposarcoma, showing a moderate uptake of Tc-99m DTPA and greater than 20% Ki-67 expression on histological slides. Meanwhile, the remaining 3 patients, diagnosed with well-differentiated liposarcoma, showed no uptake of Tc-99m DTPA and Ki-67 expression of less than 5%.

CONCLUSIONS:

This study suggests that Tc-99m DTPA renal dynamic scintigraphy provides diagnostic value in patients with retroperitoneal liposarcoma, not only in evaluating renal function but also in visualizing lesion-related radionuclide uptake, which may potentially offer further clinical insights into tumor proliferation and provide prognostic value for clinical outcomes in patients with retroperitoneal liposarcoma.

• Authors: Ying Wang, Ming Li, Shundong Dai, Yaming Li
• Journal: BioMed research international (Biomed Res Int) Vol. 2020 Pg. 9765162 ( 2020) ISSN: 2314-6141 [Electronic] United States
• PMID: 32185230 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Ying Wang et al.

Chemical References

• Radiopharmaceuticals
• Technetium Tc 99m Pentetate

Topics

• Aged
• Cell Proliferation (physiology)
• Female
• Glomerular Filtration Rate (physiology)
• Humans
• Kidney (diagnostic imaging, physiopathology)
• Kidney Function Tests (methods)
• Liposarcoma (diagnosis, diagnostic imaging, physiopathology)
• Male
• Middle Aged
• Prognosis
• Radionuclide Imaging (methods)
• Radiopharmaceuticals (administration & dosage)
• Retroperitoneal Neoplasms (diagnosis, diagnostic imaging, physiopathology)
• Retrospective Studies
• Technetium Tc 99m Pentetate (administration & dosage)
• Tomography, Emission-Computed (methods)