The objective of this retrospective study was to report treatment outcomes in dogs with
histiocytic sarcoma (HS) that were treated with
nimustine (
ACNU). This study evaluated data from 11 dogs including 5 with macroscopic
tumors that were treated in the primary setting and 6 that underwent aggressive local
therapy while being treated in the adjuvant setting. The median
ACNU starting dose was 25 mg/m2 (range, 20-30 mg/m2; 3- to 5-wk intervals, 1-8 administrations). The median overall survival in the primary and adjuvant settings was 120 days (median progression-free survival [PFS], 63 days) and 400 days (median PFS, 212 days), respectively.
Neutropenia was observed in eight cases (grade 1, n = 1; grade 2, n = 2; grade 3, n = 2; grade 4, n = 3) with nadir neutrophil count at 1 wk after
ACNU administration. Mild gastrointestinal toxicity (grade 1-2) was observed in three cases.
ACNU was well tolerated and showed a similar outcome to that seen for
lomustine, which is a
drug commonly used to treat canine HS, in terms of overall survival and PFS in the current study population. Further investigations will need to be undertaken to definitively determine if
ACNU is an appropriate alternative to
lomustine for the treatment of HS.