[Immunohistochemical study of tubulovillosis adenoma tubulovillous intestinal adenoma in the elderly.]

Abstract

Frequency indices of tubulovillous adenoma are higher than the ones of colorectal cancer, and probably, the majority of adenomas are prone to malignancy. It is often impossible to determine which adenoma tends to tumorous neoplasia. However, increase in the adenomas and expressed dysplasia contribute to adenomas malignant transformation. In this regard, the purpose of the study is to evaluate cellular proliferation, apoptosis, beta-catenin in tubulovillous intestinal adenomas with varying degrees of dysplasia. The study used biopsy materials of tubulovillous adenomas obtained from 50 patients who underwent ectomy. After resection the adenomas were cut by the maximum size for the full thickness of tunicae mucosae, muscularis be included into the section. Immunohistochemical reactions used a cellular proliferation marker (Ki-67), that of apoptosis (P-53), of a transcription factor (β-catenin). In tubulovillous adenomas with the low grade dysplasia degree there are low indicators of cellular proliferation and apoptosis, located primarily in basal glandular segments. As dysplasia degree increases, cellular division in the glandular epithelium intensifies and nuclear expression of beta-catenin appears as well. Against the background of a meaningful increase in cellular proliferation, a small number of cells in apoptotic condition are revealed. Thus, increased indicators of Ki-67 and β-catenin in a tubulovillous adenomas in high grade dysplasia contributes to limiting cellular differentiation, violates intercellular contacts.

• Authors: O V Vorobeva, A A Fomina, N E Gimaldinova
• Journal: Advances in gerontology = Uspekhi gerontologii (Adv Gerontol) Vol. 32 Issue 6 Pg. 959-963 ( 2019) ISSN: 1561-9125 [Print] Russia (Federation)
• PMID: 32160435 (Publication Type: Journal Article)

Chemical References

• beta Catenin

Topics

• Adenoma, Villous (pathology)
• Aged
• Apoptosis
• Cell Proliferation
• Colorectal Neoplasms (pathology)
• Humans
• Immunohistochemistry
• beta Catenin