Radiotherapy with apatinib for recurrence of malignant phyllodes tumor of the breast: A case report.

Abstract

RATIONALE:

Malignant phyllodes tumors of the breast are rare, and there are currently no guidelines and a large number of clinical trials to guide the treatment of recurrence tumor. Here we reported a case of radiotherapy with apatinib for the treatment of recurrent malignant phyllodes tumor of the breast.

PATIENT CONCERNS:

A 58-year-old patient with massive breast mass was admitted to our hospital. Two months after surgical treatment, the tumor recurred in the chest wall scar.

DIAGNOSES:

The histopathologic diagnoses was right breast malignant phyllodes tumor with chondrosarcomas and osteosarcomas in some areas.

INTERVENTIONS:

The patient was first treated with surgery. Malignant phyllodes tumor recurred in the chest wall two months after surgery and was treated with radiotherapy and apatinib.

OUTCOMES:

With surgery, radiotherapy and apatinib treatment, the patient still died within several months.

LESSONS:

Apatinib and radiotherapy failed to obtain good therapeutic effect in the recurrence of breast malignant phyllodes tumor in this case.

• Authors: Hong Wu, Lei Li, Jing Yang, Chen Guo, Weiming Zhang, Hui Wang
• Journal: Medicine (Medicine (Baltimore)) Vol. 99 Issue 3 Pg. e18808 (Jan 2020) ISSN: 1536-5964 [Electronic] United States
• PMID: 32011486 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Pyridines
• apatinib

Topics

• Antineoplastic Agents (therapeutic use)
• Breast Neoplasms (diagnostic imaging, pathology, therapy)
• Chemoradiotherapy
• Fatal Outcome
• Female
• Humans
• Middle Aged
• Neoplasm Recurrence, Local (diagnostic imaging, therapy)
• Phyllodes Tumor (diagnostic imaging, secondary, therapy)
• Pyridines (therapeutic use)