HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Impact of intraoperative indocyanine green fluorescence angiography on anastomotic leakage after laparoscopic sphincter-sparing surgery for malignant rectal tumors.

AbstractPURPOSE:
Whether indocyanine green fluorescence angiography (ICG-FA) during rectal surgery is effective in reducing anastomotic leakage remains unclear. This study aimed to investigate the effect of intraoperative ICG-FA on anastomotic leakage after sphincter-sparing surgery for malignant rectal tumors.
METHODS:
This was a retrospective, single-center cohort study conducted on 852 consecutive patients who underwent laparoscopic sphincter-sparing surgery from January 2007 to June 2017 at our institution. The incidence of anastomotic leakage was compared between patients who underwent ICG-FA to determine the proximal resection margin and those in whom this technique was not performed, using logistic regression analysis, including propensity score.
RESULTS:
A total of eight patients were excluded (one patient with previous low anterior resection and seven patients who underwent simultaneous resection for other primary cancers), resulting in 844 patients being analyzed. Before propensity score matching, 141 patients (16.7%) who underwent ICG-FA were compared with 703 patients (83.3%) in whom ICG-FA was not performed. The incidence of anastomotic leakage was 2.8% (4/141) in the ICG-FA group and 12.4% (87/703) in the control group (p = 0.001). After propensity score matching (n = 420), the patient characteristics between the two groups were well balanced, and the incidence of anastomotic leakage was 2.8% (4/141) in the ICG-FA group and 13.6% (38/279) in the control group (p = 0.001). Logistic regression analyses using propensity score showed that patients who underwent ICG-FA had significantly lower odds of anastomotic leakage.
CONCLUSION:
Intraoperative ICG-FA is a promising method to reduce anastomotic leakage after laparoscopic rectal surgery.
AuthorsHiro Hasegawa, Yuichiro Tsukada, Masashi Wakabayashi, Shogo Nomura, Takeshi Sasaki, Yuji Nishizawa, Koji Ikeda, Tetsuo Akimoto, Masaaki Ito
JournalInternational journal of colorectal disease (Int J Colorectal Dis) Vol. 35 Issue 3 Pg. 471-480 (Mar 2020) ISSN: 1432-1262 [Electronic] Germany
PMID31907595 (Publication Type: Journal Article)
Chemical References
  • Indocyanine Green
Topics
  • Aged
  • Anal Canal (surgery)
  • Anastomotic Leak (diagnostic imaging, etiology)
  • Cohort Studies
  • Female
  • Fluorescein Angiography
  • Humans
  • Indocyanine Green (chemistry)
  • Intraoperative Care
  • Laparoscopy (adverse effects)
  • Logistic Models
  • Male
  • Middle Aged
  • Organ Sparing Treatments
  • Perfusion
  • Rectal Neoplasms (surgery)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: