Quinolone nonsusceptibility among enteric pathogens isolated from international travelers - Foodborne Diseases Active Surveillance Network (FoodNet) and National Antimicrobial Monitoring System (NARMS), 10 United States sites, 2004 - 2014.

Abstract

Gastrointestinal illnesses are the most frequently diagnosed conditions among returning U.S. travelers. Although most episodes of travelers' diarrhea do not require antibiotic therapy, fluoroquinolones (a type of quinolone antibiotic) are recommended for treatment of moderate and severe travelers' diarrhea as well as many other types of severe infection. To assess associations between quinolone susceptibility and international travel, we linked data about isolate susceptibility in NARMS to cases of enteric infections reported to FoodNet. We categorized isolates as quinolone-nonsusceptible (QNS) if they were resistant or had intermediate susceptibility to ≥1 quinolone. Among 1,726 travel-associated infections reported to FoodNet with antimicrobial susceptibility data in NARMS during 2004-2014, 56% of isolates were quinolone-nonsusceptible, of which most (904/960) were Campylobacter. International travel was associated with >10-fold increased odds of infection with quinolone-nonsusceptible bacteria. Most QNS infections were associated with travel to Latin America and the Caribbean (390/743; 52%); however, the greatest risk of QNS infection was associated with travel to Africa (120 per 1,000,000 passenger journeys). Preventing acquisition and onward transmission of antimicrobial-resistant enteric infections among travelers is critical.

• Authors: Julian E Grass, Sunkyung Kim, Jennifer Y Huang, Stephanie M Morrison, Andre E McCullough, Christy Bennett, Cindy R Friedman, Anna Bowen
• Journal: PloS one (PLoS One) Vol. 14 Issue 12 Pg. e0225800 ( 2019) ISSN: 1932-6203 [Electronic] United States
• PMID: 31800600 (Publication Type: Historical Article, Journal Article)

Chemical References

• Quinolones

Topics

• Drug Resistance, Microbial
• Foodborne Diseases (drug therapy, epidemiology, history, microbiology)
• History, 21st Century
• Humans
• Intestinal Diseases (drug therapy, epidemiology, history, microbiology)
• Odds Ratio
• Population Surveillance
• Quinolones (pharmacology)
• Travel
• Travel-Related Illness
• United States (epidemiology)