Qualitative assessment of EOB-GD-DTPA and Gd-BT-DO3A MR contrast studies in HCC patients and colorectal liver metastases.

Abstract

AIM:

To compare liver-specific EOB-GD-DTPA and liver-non-specific Gd-BT-DO3A MR, in hepatocellular carcinoma (HCC) and liver colorectal metastases.

MATERIAL AND METHODS:

Seventy HCC patients with 158 nodules and 90 colorectal liver metastases (mCRC) with 370 lesions were included in the retrospective analysis. HCC patients underwent MR at 0 time (MR0), after 3 (MR3) and 6 months (MR6) using two different CM; 69 mCRC patients underwent MR with Gd-EOB-BTPA and 21 mCRC patients with Gd-BT-DO3A. We evaluated arterial phase hyperenhancement, lesion-to-liver contrast during portal phase, hepatobiliary phase parenchymal hyperenhancement.

RESULTS:

In HCC patients arterial phase hyperenhancement degree was statistically higher (p = 0.03) with Gd-BT-DO3A (mean 4) than GD-EOB-DTPA (mean 2.6), while we found no significant statistical differences among mean (2.6) values at MR0 and MR6 using GD-EOB-DTPA. For all 209 patients underwent Gd-EOB-DTPA, we found that lesion-to-liver contrast during portal phase mean value was 4 while for patients underwent MR with Gd-BT-DO3A was 3 (p = 0.04). For HCC hepatobiliary phase parenchymal hyperenhancement mean value was 2.4. For mCRC patients: among 63 patients underwent previous chemotherapy hepatobiliary phase parenchymal hyperenhancement mean value was 3.1 while for 6 patients no underwent previous chemotherapy was 4 (p = 0.05).

CONCLUSIONS:

Gd-EOB-DTPA should be chosen in pre surgical setting in patients with colorectal liver metastases.

• Authors: Vincenza Granata, Roberta Fusco, Francesca Maio, Antonio Avallone, Guglielmo Nasti, Raffaele Palaia, Vittorio Albino, Roberto Grassi, Francesco Izzo, Antonella Petrillo
• Journal: Infectious agents and cancer (Infect Agent Cancer) Vol. 14 Pg. 40 ( 2019) ISSN: 1750-9378 [Print] England
• PMID: 31798677 (Publication Type: Journal Article)
• Copyright: © The Author(s). 2019.