[Opsoclonus myoclonus syndrome secondary to abdominal neuroblastoma. Presentation of a pediatric clinical case].

Abstract

Opsoclonus-myoclonus syndrome is a rare disorder among pediatric patients. The diagnosis is clinical and is characterized by the presence of at least three of the following: opsoclonus, myoclonus, ataxia, irritability and sleep disorders. In over 50 % of cases it is associated with the presence of Neuroblastoma. It is a disorder of immune origin and its treatment is based on immunosuppressants, immunomodulators and tumor resection in cases secondary to Neuroblastoma. Up to 70 % to 80 % of cases may present neurological sequelae, depending on the cause, the initial severity of symptoms and the delay of proper treatment. We present the case of a 2-year-old male with diagnosis of opsoclonus-myoclonus syndrome secondary to a left adrenal Neuroblastoma. Tumor resection and treatment with corticosteroids, immunoglobulin and rituximab were performed.

• Authors: Gabriela Urman, Maia Leivi, Noelia Chamorro, Brenda García, Adrián Callea, Arnoldo Grosman
• Journal: Archivos argentinos de pediatria (Arch Argent Pediatr) Vol. 117 Issue 6 Pg. e651-e654 (12 01 2019) ISSN: 1668-3501 [Electronic] Argentina
• Vernacular Title: Síndrome de opsoclonus mioclonus secundario a neuroblastoma abdominal. Presentación de un caso clínico pediátrico.
• PMID: 31758904 (Publication Type: Case Reports, Journal Article)
• Copyright: Sociedad Argentina de Pediatría.

Chemical References

• Adrenal Cortex Hormones
• Immunoglobulins
• Rituximab

Topics

• Abdominal Neoplasms (complications, diagnosis, therapy)
• Adrenal Cortex Hormones (administration & dosage)
• Adrenal Gland Neoplasms (complications, diagnosis, therapy)
• Child, Preschool
• Combined Modality Therapy
• Humans
• Immunoglobulins (administration & dosage)
• Male
• Neuroblastoma (complications, diagnosis, therapy)
• Opsoclonus-Myoclonus Syndrome (diagnosis, etiology)
• Rituximab (administration & dosage)