Recently, a growing number of
ADP ribosylation factor (ARF) family members has been suggested to be critical in
tumorigenesis. However, the effects of most ARF members on
lung adenocarcinoma pathogenesis are still not well disclosed yet. In this study, ARF-like
GTPase 14 (ARL14) was screened as an important prognostic factor of
lung adenocarcinoma from The
Cancer Genome Atlas (TCGA) database and validated by our in vitro experiments. It was found that silencing of ARL14 gene inhibited cell proliferation and the abilities of cell migration and invasion, and it also attenuated radiation damage of
lung adenocarcinoma cells but had no effect on the proliferation of normal lung cells. Notably, ARL14
siRNA blocked the
extracellular signal-regulated kinase (ERK)/p38 signaling pathway and induced cell cycle arrest in G0 phase, ultimately leading to cell dormancy. Moreover, ARL14
siRNA enhanced the expression of cell death activator DFFA-like effector (CIDEC) that had opposite roles in cell proliferation and migration to ALR14. Collectively, our results suggest that ARL14 has an important role in the pathogenesis of
lung adenocarcinoma through CIDEC/ERK/p38 signaling pathway, and thus it could be applied as a new candidate of prognosis
indicator and/or therapeutic target of
lung adenocarcinoma.