IL-17 receptor-based signaling and implications for disease.

Abstract

IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes, including host defense, tissue repair, the pathogenesis of inflammatory disease and the progression of cancer. In contrast to its profound impact in vivo, IL-17 exhibits surprisingly moderate activity in cell-culture models, which presents a major knowledge gap about the molecular mechanisms of IL-17 signaling. Emerging studies are revealing a new dimension of complexity in the IL-17 pathway that may help explain its potent and diverse in vivo functions. Discoveries of new mRNA stabilizers and receptor-directed mRNA metabolism have provided insights into the means by which IL-17 cooperates functionally with other stimuli in driving inflammation, whether beneficial or destructive. The integration of IL-17 with growth-receptor signaling in specific cell types offers new understanding of the mitogenic effect of IL-17 on tissue repair and cancer. This Review summarizes new developments in IL-17 signaling and their pathophysiological implications.

• Authors: Xiaoxia Li, Rami Bechara, Junjie Zhao, Mandy J McGeachy, Sarah L Gaffen
• Journal: Nature immunology (Nat Immunol) Vol. 20 Issue 12 Pg. 1594-1602 (12 2019) ISSN: 1529-2916 [Electronic] United States
• PMID: 31745337 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Interleukin-17
• Receptors, Interleukin-7

Topics

• Animals
• Cells, Cultured
• Humans
• Immune System Diseases (immunology)
• Inflammation (immunology)
• Interleukin-17 (metabolism)
• Neoplasms (immunology)
• Receptors, Interleukin-7 (metabolism)
• Signal Transduction