Abstract | BACKGROUND: CASE PRESENTATION: A 64-year-old Japanese woman presented with genital bleeding. She was diagnosed as having stage IB1 squamous cell cervical cancer and subsequently treated with radiotherapy. Approximately 2 years after the curative radiotherapy, she developed itching, skin rash, and small nodules on her left femoral and pubic area. Slight 18F-fluorodeoxyglucose uptake was detected at her left femoral skin on positron emission tomography with computed tomography. A histopathological examination was performed on a biopsy sample from an erythematous macule on her left femoral skin and vulva. Consequently, she was diagnosed as having cutaneous lymphangitis carcinomatosa arising from cervical cancer. Paclitaxel (135 mg/m2), cisplatin (50 mg/m2), and bevacizumab (15 mg/kg) combination therapy was administered every 21 days. Both itching and rash improved after three treatment cycles. After the completion of six cycles, skin erythema in the femoral and vulval area disappeared completely. Our patient experienced a 25-month symptom-free interval after the last chemotherapy session. CONCLUSION:
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Authors | Fumihiro Nakamura, Manabu Seino, Yuriko Suzuki, Hirotsugu Sakaki, Takeshi Sudo, Tsuyoshi Ohta, Seiji Tsutsumi, Satoru Nagase |
Journal | Journal of medical case reports
(J Med Case Rep)
Vol. 13
Issue 1
Pg. 328
(Nov 07 2019)
ISSN: 1752-1947 [Electronic] England |
PMID | 31699140
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Bevacizumab
- Paclitaxel
- Cisplatin
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bevacizumab
(therapeutic use)
- Carcinoma, Squamous Cell
(radiotherapy)
- Cisplatin
(therapeutic use)
- Female
- Humans
- Lymphangitis
(drug therapy, pathology)
- Middle Aged
- Paclitaxel
(therapeutic use)
- Treatment Outcome
- Uterine Cervical Neoplasms
(radiotherapy)
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