Protective Immunity and New Vaccines for Lyme Disease.

Abstract

Lyme disease, caused by some Borrelia burgdorferi sensu lato, is the most common tick-borne illness in the Northern Hemisphere and the number of cases, and geographic spread, continue to grow. Previously identified B. burgdorferi proteins, lipid immunogens, and live mutants lead the design of canonical vaccines aimed at disrupting infection in the host. Discovery of the mechanism of action of the first vaccine catalyzed the development of new strategies to control Lyme disease that bypassed direct vaccination of the human host. Thus, novel prevention concepts center on proteins produced by B. burgdorferi during tick transit and on tick proteins that mediate feeding and pathogen transmission. A burgeoning area of research is tick immunity as it can unlock mechanistic pathways that could be targeted for disruption. Studies that shed light on the mammalian immune pathways engaged during tick-transmitted B. burgdorferi infection would further development of vaccination strategies against Lyme disease.

• Authors: Maria Gomes-Solecki, Paul M Arnaboldi, P Bryon Backenson, Jorge L Benach, Christopher L Cooper, Raymond J Dattwyler, Maria Diuk-Wasser, Erol Fikrig, J W Hovius, Will Laegreid, Urban Lundberg, Richard T Marconi, Adriana R Marques, Philip Molloy, Sukanya Narasimhan, Utpal Pal, Joao H F Pedra, Stanley Plotkin, Daniel L Rock, Patricia Rosa, Sam R Telford, Jean Tsao, X Frank Yang, Steven E Schutzer
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 70 Issue 8 Pg. 1768-1773 (04 10 2020) ISSN: 1537-6591 [Electronic] United States
• PMID: 31620776 (Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.

Chemical References

• Vaccines

Topics

• Animals
• Borrelia burgdorferi
• Humans
• Ixodes
• Lyme Disease (prevention & control)
• Ticks
• Vaccination
• Vaccines