Nitric oxide and its derivatives in the cancer battlefield.

Abstract

Elevated levels of reactive nitrogen species, alteration in redox balance and deregulated redox signaling are common hallmarks of cancer progression and chemoresistance. However, depending on the cellular context, distinct reactive nitrogen species are also hypothesized to mediate cytotoxic activity and are thus used in anticancer therapies. We present here the dual face of nitric oxide and its derivatives in cancer biology. Main derivatives of nitric oxide, such as nitrogen dioxide and peroxynitrite cause cell death by inducing protein and lipid peroxidation and/or DNA damage. Moreover, they control the activity of important protein players within the pro- and anti-apoptotic signaling pathways. Thus, the control of intracellular reactive nitrogen species may become a sophisticated tool in anticancer strategies.

• Authors: Anna Kamm, Paulina Przychodzen, Alicja Kuban-Jankowska, Dagmara Jacewicz, Aleksandra M Dabrowska, Stephan Nussberger, Michal Wozniak, Magdalena Gorska-Ponikowska
• Journal: Nitric oxide : biology and chemistry (Nitric Oxide) Vol. 93 Pg. 102-114 (12 01 2019) ISSN: 1089-8611 [Electronic] United States
• PMID: 31541733 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Nitric Oxide Donors
• Proteins
• Peroxynitrous Acid
• Nitric Oxide

Topics

• Animals
• Cell Line, Tumor
• DNA Damage (drug effects)
• Humans
• Metal Nanoparticles (chemistry, therapeutic use)
• Mitochondria (drug effects)
• Neoplasms (drug therapy)
• Nitric Oxide (chemistry, metabolism)
• Nitric Oxide Donors (pharmacology, therapeutic use)
• Peroxynitrous Acid (chemistry, metabolism)
• Protein Processing, Post-Translational (drug effects)
• Proteins (chemistry, metabolism)