[Locally Advanced Sigmoid Colon Cancer in an Elderly Patient Treated with Curative Resection after Successful Panitumumab Treatment].

Abstract

An 84-year-old woman had locally advanced sigmoid colon cancer that was unresectable because of deep invasion in the left pelvic wall. Transverse double-barrel colostomy was performed owing to stenosis in the sigmoid colon. The patient's performance status score was 2, and it was difficult to administer cytotoxic chemotherapy. Single-agent panitumumab chemotherapy was initiated. In addition, although S-1 was administered for 4 days in the fourth cycle, it was discontinued owing to drug intolerance. Panitumumab was administered seven times. The tumor size markedly reduced, and sigmoid colectomy was performed. Thus, single-agent panitumumab chemotherapy is a possible treatment option for advanced colorectal cancer in elderly patients.

• Authors: Toshihiko Goto, Masahiko Okamura, Kunihiko Tsuboi, You Mizukami, Shuichi Ota, Yukito Adach
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 46 Issue 8 Pg. 1311-1313 (Aug 2019) ISSN: 0385-0684 [Print] Japan
• PMID: 31501377 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Immunological
• Panitumumab

Topics

• Aged, 80 and over
• Antineoplastic Agents, Immunological (therapeutic use)
• Colon, Sigmoid
• Female
• Humans
• Panitumumab (therapeutic use)
• Sigmoid Neoplasms (drug therapy, surgery)