PIPERACILLIN/TAZOBACTAM IN CONTINUOUS INFUSION VERSUS INTERMITTENT INFUSION IN CHILDREN WITH FEBRILE NEUTROPENIA.

Abstract

Background:

Febrile neutropenia (FN) is a common complication in children who receive chemotherapy for cancer.

Objective:

The objective of this study was to evaluate the clinical efficacy of the continuous versus intermittent infusion of piperacillin/tazobactam (TZP) in febrile neutropenic pediatric patients.

Methods:

This is a non-blinded randomized controlled clinical trial. Eligible group consisted of hemato-oncological patients with FN who were candidates to receive TZP. Patients were randomized to one of two groups: Group 1 received antibiotic treatment through intravenous intermittent infusion of TZP 300 mg/kg/day based on piperacillin, divided into four doses, not exceeding 16 g/day; Group 2 received an initial TZP loading dose of 75 mg/kg infusion over 30 min, and then a continuous infusion of TZP 300 mg/kg/day through central line with pump over 24 h.

Results:

There were 176 episodes that could be assessed, 100 in Group 1 and 76 in Group 2. There was no statistically significant difference in treatment failure in the experimental group (continuous infusion) compared with the intermittent group, 21% versus 13% (p = 0.15). The increase in the absolute risk reduction was 0.08% (95% confidence interval 0.12-0.30), and the number needed to treat was 12.4. One patient in each group died.

Conclusions:

There were no differences in fever resolution, clinical cure rate, or mortality when comparing the continuous with the intermittent TZP infusion.

• Authors: Fortino Solórzano-Santos, Anai Quezada-Herrera, Yazmín Fuentes-Pacheco, Genoveva Rodríguez-Coello, Carlos E Aguirre-Morales, Dassaev Izelo-Flores, Onofre Muñoz-Hernández, María G Miranda-Novales, María G Labra-Zamora
• Journal: Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion (Rev Invest Clin) Vol. 71 Issue 4 Pg. 283-290 ( 2019) ISSN: 0034-8376 [Print] Mexico
• PMID: 31448789 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright: © 2019 Permanyer.

Chemical References

• Anti-Bacterial Agents
• Antineoplastic Agents
• Piperacillin, Tazobactam Drug Combination

Topics

• Adolescent
• Anti-Bacterial Agents (administration & dosage)
• Antineoplastic Agents (administration & dosage, adverse effects)
• Child
• Child, Preschool
• Drug Administration Schedule
• Febrile Neutropenia (drug therapy)
• Female
• Humans
• Infant
• Infusions, Intravenous
• Male
• Neoplasms (drug therapy)
• Piperacillin, Tazobactam Drug Combination (administration & dosage)