Controlled trial of intravesical noxythiolin in the prevention of infection following outflow tract surgery.

Abstract

A randomised control trial was undertaken in 100 consecutive patients undergoing endoscopic surgery for outflow tract obstruction to assess the efficacy of noxythiolin in preventing post-operative bacteriuria; 1% noxythiolin or sterile water was instilled at the time of catheter removal. The incidence of bacteriuria in the treated group (7/50) was significantly lower than in the control group (19/50). This was statistically significant. This difference was more marked in patients who had been catheterised for retention of urine. There was no difference in the complication rate despite a reduction of infection in the treated group.

• Authors: M A Jones, A Hasan
• Journal: British journal of urology (Br J Urol) Vol. 62 Issue 4 Pg. 311-4 (Oct 1988) ISSN: 0007-1331 [Print] England
• PMID: 3142635 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Noxythiolin
• Thiourea

Topics

• Administration, Intravesical
• Aged
• Aged, 80 and over
• Bacteriuria (prevention & control)
• Clinical Trials as Topic
• Humans
• Middle Aged
• Noxythiolin (administration & dosage, therapeutic use)
• Postoperative Complications (prevention & control)
• Thiourea (analogs & derivatives)
• Urethral Obstruction (surgery)
• Urinary Bladder Neck Obstruction (surgery)