Hydrogen peroxide-producing NADPH oxidases and the promotion of migratory phenotypes in cancer.

Abstract

The cellular microenvironment plays a critical role in cancer initiation and progression. Exposure to oxidative stress, specifically hydrogen peroxide (H2O2), has been linked to aberrant cellular signaling through which the development of cancer may be promoted. Three members of the NADPH oxidase family (NOX4, DUOX1 and DUOX2) explicitly generate this non-radical oxidant in a wide range of tissues, often in support of the inflammatory response. This review summarizes the contributions of each H2O2-producing NOX to the invasive behaviors of tumors and/or the epithelial-mesenchymal transition (EMT) in cancer that plays an essential role in metastasis. Tissue localization in tumorigenesis is also highlighted, with patient-derived TCGA microarray data profiled across 31 cancer cohorts to provide a comprehensive guide to the relevance of NOX4/DUOX1/DUOX2 in cancer studies.

• Authors: Jennifer L Meitzler, Mariam M Konaté, James H Doroshow
• Journal: Archives of biochemistry and biophysics (Arch Biochem Biophys) Vol. 675 Pg. 108076 (10 30 2019) ISSN: 1096-0384 [Electronic] United States
• PMID: 31415727 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Published by Elsevier Inc.

Chemical References

• Hydrogen Peroxide
• Dual Oxidases
• NADPH Oxidases
• DUOX2 protein, human

Topics

• Carcinogenesis
• Dual Oxidases (genetics)
• Epithelial-Mesenchymal Transition (genetics)
• Gene Silencing
• Humans
• Hydrogen Peroxide (metabolism)
• NADPH Oxidases (biosynthesis)
• Neoplasm Metastasis
• Neoplasms (metabolism, pathology)
• Oxidative Stress
• Phenotype
• Tumor Microenvironment