Olanexidine gluconate versus povidone-iodine for preventing surgical-site infection in orthopaedic surgery: A retrospective study.

Abstract

BACKGROUND:

Olanexidine gluconate (OLG) is a newly developed skin antiseptic, which is effective against a broad range of bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus. The purpose of this study was to evaluate the bactericidal efficacy and safety of OLG in orthopaedic surgery.

METHODS:

This retrospective study included a total of 1103 patients who underwent clean orthopaedic surgery. They were divided into two groups: 556 patients who were treated with OLG (OLG group), and 547 patients who were treated with povidone-iodine (PVP-I) (PVP-I group). The efficacy and the safety outcomes were measured as the rate of surgical-site infection (SSI) within 30 days after surgery and the rate of adverse skin reaction, respectively.

RESULTS:

There was no significant difference between the OLG group and PVP-I group (1.80% vs. 2.38%; p = 0.50) based on the overall rate of SSI. Also, there was no significant difference in both superficial incisional infections (1.08% vs. 2.01%; p = 0.21) and deep incisional infections (0.72% vs. 0.37%; p = 0.35). The overall rate of adverse skin reaction was significantly higher in the OLG group than in the PVP-I group (2.16% vs. 0.73%; p = 0.047).

CONCLUSIONS:

This retrospective study demonstrated that OLG has an efficacy similar to PVP-I in preventing SSI in clean orthopaedic surgery. However, adverse skin reactions at the application site of OLG requires more attention.

• Authors: Mitsuru Asukai, Tsuyoshi Ohishi, Tomotada Fujita, Daisuke Suzuki, Tatsuya Nishida, Kaori Sugiura, Yukihiro Matsuyama
• Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (J Orthop Sci) Vol. 24 Issue 6 Pg. 1125-1129 (Nov 2019) ISSN: 1436-2023 [Electronic] Japan
• PMID: 31395421 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2019. Published by Elsevier B.V.

Chemical References

• Anti-Infective Agents, Local
• Biguanides
• Glucuronates
• Povidone-Iodine
• olanexidine gluconate

Topics

• Adult
• Aged
• Aged, 80 and over
• Anti-Infective Agents, Local (therapeutic use)
• Biguanides (therapeutic use)
• Female
• Glucuronates (therapeutic use)
• Humans
• Male
• Middle Aged
• Orthopedic Procedures
• Povidone-Iodine (therapeutic use)
• Retrospective Studies
• Surgical Wound Infection (microbiology, prevention & control)