The presence of CA19-9 in serum and saliva from Lewis blood-group negative cancer patients.

Abstract

Eighteen cancer patients showed high levels of CA19-9 in sera, even though the blood-group phenotypes of their red blood cells were Le(a-b-). Seven of these patients (group I) were determined as Le(a-b-) from both red blood cells and saliva consistently, whereas eleven other patients (group II) secreted either Le(a) or Le(b) antigen in saliva and showed the expression of incompatible Lewis blood-group antigens. GDP-fucose: N-acetyl-glucosaminide alpha(1----4)-L-fucosyltransferase was demonstrated to be present in salivas from both group I and group II. These results suggest that a cancer-associated alteration of Lewis blood-group antigen expression occurs in cancer patients.

• Authors: S Yazawa, T Asao, H Izawa, Y Miyamoto, K L Matta
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 79 Issue 4 Pg. 538-43 (Apr 1988) ISSN: 0910-5050 [Print] Japan
• PMID: 3133342 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Neoplasm
• Antigens, Tumor-Associated, Carbohydrate
• Enzyme Precursors
• Lewis Blood Group Antigens
• Guanosine Diphosphate Fucose
• Fucosyltransferases
• 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

Topics

• Antigens, Neoplasm (analysis)
• Antigens, Tumor-Associated, Carbohydrate
• Blood Grouping and Crossmatching
• Enzyme Precursors (blood)
• Female
• Fucosyltransferases (blood)
• Guanosine Diphosphate Fucose
• Humans
• Lewis Blood Group Antigens
• Male
• Neoplasms (blood, enzymology, immunology)
• Phenotype
• Saliva (enzymology, immunology)