Abstract | BACKGROUND: While multiagent chemotherapy has dramatically improved the prognosis of sarcoma, the novel chemotherapeutics have hardly developed over the past 30 years. Caffeine can induce apoptosis, delays in cell cycle progression and can enhance the cytocidal effects of anti- cancer agents. Citrate has been reported to enhance the cytocidal effect of cisplatin in gastric cancer in vitro. However its effect in sarcoma cells had not been reported. METHODS: RESULTS: CONCLUSIONS:
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Authors | Kensaku Abe, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Hiroyuki Tsuchiya |
Journal | BMC cancer
(BMC Cancer)
Vol. 19
Issue 1
Pg. 689
(Jul 15 2019)
ISSN: 1471-2407 [Electronic] England |
PMID | 31307409
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Central Nervous System Stimulants
- Citrates
- Caffeine
- Cisplatin
- caffeine citrate
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Apoptosis
(drug effects)
- Bone Neoplasms
(drug therapy)
- Caffeine
(administration & dosage, therapeutic use)
- Cell Cycle Checkpoints
(drug effects)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Central Nervous System Stimulants
(administration & dosage, therapeutic use)
- Cisplatin
(administration & dosage, therapeutic use)
- Citrates
(administration & dosage, therapeutic use)
- Drug Synergism
- Drug Therapy, Combination
- Female
- Fibrosarcoma
(drug therapy)
- Humans
- Membrane Potential, Mitochondrial
(drug effects)
- Mice
- Mice, Nude
- Osteosarcoma
(drug therapy)
- Treatment Outcome
- Tumor Burden
- Xenograft Model Antitumor Assays
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