HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Linalyl acetate prevents three related factors of vascular damage in COPD-like and hypertensive rats.

Abstract
Preventing vascular damage is considered an effective strategy in patients who suffer from chronic obstructive pulmonary disease (COPD) with hypertension. Here, we investigated vascular damage in COPD-like and hypertensive rats, which demonstrated the presence of the three related factors of COPD with hypertension. These include elevated systolic blood pressure (SBP), serum malondialdehyde (MDA) and serum lactate dehydrogenase (LDH), which are positively correlated with vascular damage in patients. In addition to increases in these three related factors, COPD-like and hypertensive rats exhibited increased levels of pro-inflammatory mediators, such as tumor necrosis factor-α, interleukin-6, and matrix metallopeptidase-9 in bronchoalveolar lavage fluid, and enlargement of alveolar airspaces, recapitulating clinical findings in previous studies of patients. Moreover, the appearance of these related factors was prevented by linalyl acetate. Our results provide novel insight into the potential of LA to prevent vascular damage and elevated SBP, serum MDA and serum LDH in COPD with hypertension, and could lead to an alternative strategy for preventing vascular damage for patients who suffered from COPD with hypertension in a clinical setting.
AuthorsYu Shan Hsieh, You Kyoung Shin, A Young Han, Soonho Kwon, Geun Hee Seol
JournalLife sciences (Life Sci) Vol. 232 Pg. 116608 (Sep 01 2019) ISSN: 1879-0631 [Electronic] Netherlands
PMID31254583 (Publication Type: Journal Article)
CopyrightCopyright © 2019 Elsevier Inc. All rights reserved.
Chemical References
  • Monoterpenes
  • Malondialdehyde
  • linalyl acetate
  • L-Lactate Dehydrogenase
Topics
  • Animals
  • Blood Pressure (physiology)
  • Bronchoalveolar Lavage Fluid
  • Disease Models, Animal
  • Hypertension (drug therapy, pathology, physiopathology)
  • L-Lactate Dehydrogenase (analysis, blood)
  • Lung (pathology)
  • Male
  • Malondialdehyde (analysis, blood)
  • Monoterpenes (pharmacology)
  • Pulmonary Disease, Chronic Obstructive (drug therapy, pathology, physiopathology)
  • Rats
  • Rats, Sprague-Dawley

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: