Abstract |
Preventing vascular damage is considered an effective strategy in patients who suffer from chronic obstructive pulmonary disease ( COPD) with hypertension. Here, we investigated vascular damage in COPD-like and hypertensive rats, which demonstrated the presence of the three related factors of COPD with hypertension. These include elevated systolic blood pressure (SBP), serum malondialdehyde (MDA) and serum lactate dehydrogenase (LDH), which are positively correlated with vascular damage in patients. In addition to increases in these three related factors, COPD-like and hypertensive rats exhibited increased levels of pro-inflammatory mediators, such as tumor necrosis factor-α, interleukin-6, and matrix metallopeptidase-9 in bronchoalveolar lavage fluid, and enlargement of alveolar airspaces, recapitulating clinical findings in previous studies of patients. Moreover, the appearance of these related factors was prevented by linalyl acetate. Our results provide novel insight into the potential of LA to prevent vascular damage and elevated SBP, serum MDA and serum LDH in COPD with hypertension, and could lead to an alternative strategy for preventing vascular damage for patients who suffered from COPD with hypertension in a clinical setting.
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Authors | Yu Shan Hsieh, You Kyoung Shin, A Young Han, Soonho Kwon, Geun Hee Seol |
Journal | Life sciences
(Life Sci)
Vol. 232
Pg. 116608
(Sep 01 2019)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 31254583
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
Chemical References |
- Monoterpenes
- Malondialdehyde
- linalyl acetate
- L-Lactate Dehydrogenase
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Topics |
- Animals
- Blood Pressure
(physiology)
- Bronchoalveolar Lavage Fluid
- Disease Models, Animal
- Hypertension
(drug therapy, pathology, physiopathology)
- L-Lactate Dehydrogenase
(analysis, blood)
- Lung
(pathology)
- Male
- Malondialdehyde
(analysis, blood)
- Monoterpenes
(pharmacology)
- Pulmonary Disease, Chronic Obstructive
(drug therapy, pathology, physiopathology)
- Rats
- Rats, Sprague-Dawley
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