The impact of age on long-term behavioral and neurochemical parameters in an animal model of severe sepsis.

Abstract

This study aimed to evaluate behavioral and neurochemical parameters in adult (180-day-old) and young (60-day-old) rats subjected to sepsis. Sepsis was induced by cecal ligation and perforation (CLP). Thirty days after surgery, behavioral tests were performed, and the β-amyloid content, oxidative damage, and cytokine levels were measured in the hippocampus and prefrontal cortex. In both adult and young rats, sepsis impaired the inhibitory avoidance task performance and increased immobility time in the forced swimming test. However, the adult septic rats had a higher immobility time compared to the young rats. Both sepsis and aging induced brain inflammation and oxidative damage and increased Aβ content. Sepsis along with aging had additive effects on hippocampal interleukin-1 levels and prefrontal carbonyl levels. Taken together, our results suggest that age has a minor influence on brain inflammation and behavioral alterations observed in septic rats.

• Authors: Maria Vitoria Meller Milioli, Henrique Burger, Rodrigo Olivieri, Monique Michels, Pricila Ávila, Mariane Abatti, Amanda Indalécio, Cristiane Ritter, Felipe Dal-Pizzol
• Journal: Neuroscience letters (Neurosci Lett) Vol. 708 Pg. 134339 (08 24 2019) ISSN: 1872-7972 [Electronic] Ireland
• PMID: 31226364 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• Amyloid beta-Peptides
• Interleukin-1beta
• Interleukin-6

Topics

• Age Factors
• Amyloid beta-Peptides (metabolism)
• Animals
• Behavior, Animal
• Cognition
• Depression (psychology)
• Hippocampus (metabolism)
• Interleukin-1beta (metabolism)
• Interleukin-6 (metabolism)
• Oxidative Stress
• Prefrontal Cortex (metabolism)
• Rats
• Sepsis (metabolism, psychology)
• Time Factors