[Maternal Tumor Disease as a Reason for Repeated Test Failure in Cell-Free DNA Screening].

Abstract

Noninvasive prenatal testing (NIPT) is a screening test for fetal chromosome disorders. Recent studies show an incidental detection of maternal malignancies in NIPT diagnostics, where the simultaneous presence of multiple aneuploidies is described as an NIPT "anomaly". In this case, the diagnosis of a maternal tumor disease was made due to a repeat NIPT failure (no call).

• Authors: Anne Karge, Oliver Graupner, Kathrin Abel, Bettina Kuschel
• Journal: Zeitschrift fur Geburtshilfe und Neonatologie (Z Geburtshilfe Neonatol) Vol. 223 Issue 3 Pg. 179-183 (Jun 2019) ISSN: 1439-1651 [Electronic] Germany
• Vernacular Title: Mütterliches Malignom in der Schwangerschaft als Ursache eines wiederholten Testversagens im nicht-invasiven Pränataltest.
• PMID: 31200400 (Publication Type: Case Reports, Journal Article)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Cell-Free Nucleic Acids

Topics

• Adult
• Aneuploidy
• Cell-Free Nucleic Acids
• Chromosome Disorders (diagnosis)
• Female
• Fetal Diseases (diagnosis, genetics)
• Genetic Testing
• Humans
• Incidental Findings
• Mass Screening
• Neoplasms (diagnosis, genetics)
• Pregnancy
• Prenatal Diagnosis