Objective: To analyze 8 cases of
paraquat lung transplantation in the world, and to explore the timing of
lung transplantation and the factors affecting prognosis. Methods: An analysis of the clinical data of a
paraquat poisoning lung transplant patient completed by The 12th People's Hospital of Guangzhou Medical University and The First People's Hospital affiliated to Guangzhou Medical University in August 2017 and literature review. Results: A 26 years old female patient was admitted to the hospital ingested 20%
paraquat solution 20ml. On the 58th day of
poisoning, she underwent double
lung transplantation under
general anesthesia. The operation was successful. Excised lungs show extensive lung
fibrosis in both lungs, which was consistent with
paraquat poisoning. Used
tacrolimus and
corticosteroids and mycophenolate antirejection, the patient discharged 46 days after surgery. 7 articles were retrieved through the search tool, and a total of 8 articles included this case were reported. Five patients who underwent
lung transplantation within 1 month after
poisoning all died, And 3 patients conducted
lung transplantation for more than 1 month after
poisoning survived; Pathogenic bacteria were isolated from the sputum in 3 of the 8 cases, all containing Pseudomonas, 2 of which died, and our case survived. Conclusion: Appropriate
transplantation time window is very important for the prognosis of
paraquat poisoning after
lung transplantation. Active treatment of the sputum pathogens, improving the donor receptor matching, and exhausting the various means to remove the
paraquat from the storage pool which may improve success rate of
lung transplantation.