Intracranial Pressure and Intracranial Elastance Monitoring in Neurocritical Care.

Abstract

Patients with acute brain injuries tend to be physiologically unstable and at risk of rapid and potentially life-threatening decompensation due to shifts in intracranial compartment volumes and consequent intracranial hypertension. Invasive intracranial pressure (ICP) monitoring therefore remains a cornerstone of modern neurocritical care, despite the attendant risks of infection and damage to brain tissue arising from the surgical placement of a catheter or pressure transducer into the cerebrospinal fluid or brain tissue compartments. In addition to ICP monitoring, tracking of the intracranial capacity to buffer shifts in compartment volumes would help in the assessment of patient state, inform clinical decision making, and guide therapeutic interventions. We review the anatomy, physiology, and current technology relevant to clinical management of patients with acute brain injury and outline unmet clinical needs to advance patient monitoring in neurocritical care.

• Authors: Thomas Heldt, Tommaso Zoerle, Daniel Teichmann, Nino Stocchetti
• Journal: Annual review of biomedical engineering (Annu Rev Biomed Eng) Vol. 21 Pg. 523-549 (06 04 2019) ISSN: 1545-4274 [Electronic] United States
• PMID: 31167100 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Topics

• Biomedical Engineering
• Brain Injuries (cerebrospinal fluid, diagnostic imaging, physiopathology)
• Critical Care
• Elasticity (physiology)
• Humans
• Intracranial Hypertension (cerebrospinal fluid, diagnosis, physiopathology)
• Intracranial Pressure (physiology)
• Models, Neurological
• Neurophysiological Monitoring (adverse effects, methods, trends)
• Pulse Wave Analysis