Roadmap to functional cure of chronic hepatitis B: An expert consensus.

Abstract

Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide. HBsAg loss is associated with functional remission and improved long-term outcome, and is considered to be a 'functional cure' (also referred to as clinical or immunologic cure) for chronic hepatitis B. This ideal goal of therapy can be achieved using optimized combination regimens with direct-acting antivirals [eg nucleos(t)ide analogues (NAs)] and immunomodulators [eg pegylated interferon alpha2a (Peg-IFN)] in selected patients with chronic hepatitis B. Among different combination therapies currently available, those with NA lead-in followed by Peg-IFN in virally suppressed patients has been demonstrated to be effective. This review provides an updated overview of the evidence supporting the use of combination therapies and summarizes expert consensus on the roadmap to attain functional cure for chronic hepatitis B patients.

• Authors: Qin Ning, Di Wu, Gui-Qiang Wang, Hong Ren, Zhi-Liang Gao, Peng Hu, Mei-Fang Han, Yan Wang, Wen-Hong Zhang, Feng-Min Lu, Fu-Sheng Wang
• Journal: Journal of viral hepatitis (J Viral Hepat) Vol. 26 Issue 10 Pg. 1146-1155 (10 2019) ISSN: 1365-2893 [Electronic] England
• PMID: 31087479 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2019 John Wiley & Sons Ltd.

Chemical References

• Antiviral Agents
• Immunologic Factors
• Interferon-alpha
• Nucleosides
• Nucleotides
• Recombinant Proteins
• Polyethylene Glycols
• peginterferon alfa-2a

Topics

• Antiviral Agents (therapeutic use)
• Consensus
• Drug Therapy, Combination (methods)
• Hepatitis B, Chronic (drug therapy)
• Humans
• Immunologic Factors (therapeutic use)
• Interferon-alpha (therapeutic use)
• Nucleosides (analogs & derivatives, therapeutic use)
• Nucleotides (therapeutic use)
• Polyethylene Glycols (therapeutic use)
• Recombinant Proteins (therapeutic use)
• Treatment Outcome