rs895819 in microRNA-27a increase stomach neoplasms risk in China: A meta-analysis.

Abstract

BACKGROUND:

Across the globe, gastric cancer is a significant public health problem. This meta-analysis was conducted to investigate the association of microRNA-27a (miRNA-27a) rs895819 with gastric cancer risk.

METHODS:

The search of databases updated on October 10, 2018 included Pubmed, Embase, Cochrane Library and Web of science. Odds ratio (ORs) and 95% confidence interval (CIs) were calculated to assess the risk of tumor.

RESULTS:

Overall meta-analysis suggested the miRNA-27a rs895819 was not related to the gastric carcinogenesis among all model including allele contrast (G vs A, pooled OR: 1.096, 95% CI: 0.962-1.249, P = 0.196), codominant model (GG vs AA, pooled OR: 1.124, 95% CI: 0.794-1.592, P = 0.590; AG vs AA, pooled OR: 1.101, 95% CI: 0.966-1.217, P = 0.060), dominant model (AG + GG vs AA, pooled OR: 1.123, 95% CI: 0.964-1.307, P = 0.136) and recessive model (GG vs AG + AA, pooled OR: 0.927, 95% CI: 0.673-1.278, P = 0.644). Interestingly, among different ethnicity group, significant relation between rs895819 and gastric cancer was observed in co-dominant model among Chinese population (AG vs AA, pooled OR: 1.158, 95% CI: 1.038-1.291, P = 0.008) but not some regions of European population (AG vs AA, pooled OR: 0.852, 95% CI: 0.632-1.148, P = 0.179).

CONCLUSIONS:

Our results find that rs895819 contributed to occurrence of gastric cancer in co-dominant model in Chinese population.

• Authors: Xiaojing Yun, Yuhuan Bai, Zhihui Li, Dongmei Wang, Yusen Zhu, Changchun Jing
• Journal: Gene (Gene) Vol. 707 Pg. 103-108 (Jul 30 2019) ISSN: 1879-0038 [Electronic] Netherlands
• PMID: 31054359 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: Copyright © 2019 Elsevier B.V. All rights reserved.

Chemical References

• MIRN27 microRNA, human
• MicroRNAs

Topics

• Asian People (genetics)
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• MicroRNAs (genetics)
• Odds Ratio
• Polymorphism, Single Nucleotide
• Stomach Neoplasms (genetics)