Polycystins and Mechanotransduction in Human Disease.

Abstract

Alterations in the process of mechanotransduction have been implicated in the pathogenesis of several diseases such as genetic diseases, osteoporosis, cardiovascular anomalies, and cancer. Several studies over the past twenty years have demonstrated that polycystins (polycystin-1, PC1; and polycystin-2, PC2) respond to changes of extracellular mechanical cues, and mediate pathogenic mechanotransduction and cyst formation in kidney cells. However, recent reports reveal the emergence of polycystins as key proteins that facilitate the transduction of mechano-induced signals in various clinical entities besides polycystic kidney disease, such as cancer, cardiovascular defects, bone loss, and deformations, as well as inflammatory processes like psoriasis. Herewith, we discuss data from recent studies that establish this role with potential clinical utility.

• Authors: Antonios N Gargalionis, Efthimia K Basdra, Athanasios G Papavassiliou
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 20 Issue 9 (May 02 2019) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 31052533 (Publication Type: Journal Article, Review)

Chemical References

• TRPP Cation Channels
• polycystic kidney disease 1 protein
• polycystic kidney disease 2 protein

Topics

• Animals
• Bone Resorption (metabolism, pathology)
• Cardiomyopathies (metabolism, pathology)
• Humans
• Mechanotransduction, Cellular
• Neoplasms (metabolism, pathology)
• Psoriasis (metabolism, pathology)
• TRPP Cation Channels (analysis, metabolism)