Abstract | BACKGROUND AND AIM: MATERIALS AND METHODS: For experiment purpose, a total of 48 SD rats were divided into four dose groups having 12 animals each. Group I was control group received only distilled water. Group II, Group III, and Group IV were treated with acetamiprid at a dose rate of 5, 20, and 40 mg/kg body weight, respectively. Rats were tested in induced pain by formalin injection and tail flick test. RESULTS: The flinch counts in formalin-induced pain in acetamiprid-treated rat were reduced in a dose-dependent manner, whereas, in tail flick test, no such altered pain behavior was observed in treated group compared to control animals. CONCLUSION:
Acetamiprid alters the centralized nociception through nAChR but could not trigger the associated signal to inhibit the nociception peripherally.
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Authors | Samiran Mondal, Saktipada Pradhan, Sunit K Mukhopadhayay |
Journal | Veterinary world
(Vet World)
Vol. 12
Issue 2
Pg. 254-257
( 2019)
ISSN: 0972-8988 [Print] India |
PMID | 31040567
(Publication Type: Journal Article)
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