Glutathione levels and activities of glutathione metabolism enzymes in patients with schizophrenia: A systematic review and meta-analysis.
Abstract | BACKGROUND: METHODS: A systematic literature search was conducted using Embase, Medline, PsycINFO, and PubMed. Original studies, in which three metabolite levels ( glutathione, glutathione disulfide, and total glutathione (glutathione+glutathione disulfide)) and five enzyme activities ( glutathione peroxidase, glutathione reductase, glutamate-cysteine ligase, glutathione synthetase, and glutathione S-transferase) were measured with any techniques in both patients with schizophrenia and healthy controls, were included. Standardized mean differences were calculated to determine the group differences in the glutathione levels with a random-effects model. RESULTS: CONCLUSIONS: Our findings suggested that there may be glutathione deficits and abnormalities in the glutathione redox cycle in patients with schizophrenia. However, given the small number of studies examined the entire glutathione system, further studies are needed to elucidate a better understanding of disrupted glutathione function in schizophrenia, which may pave the way for the development of novel therapeutic strategies in this disorder.
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Authors | Sakiko Tsugawa, Yoshihiro Noda, Ryosuke Tarumi, Yu Mimura, Kazunari Yoshida, Yusuke Iwata, Muhammad Elsalhy, Minori Kuromiya, Shin Kurose, Fumi Masuda, Shinji Morita, Kamiyu Ogyu, Eric Plitman, Masataka Wada, Takahiro Miyazaki, Ariel Graff-Guerrero, Masaru Mimura, Shinichiro Nakajima |
Journal | Journal of psychopharmacology (Oxford, England)
(J Psychopharmacol)
Vol. 33
Issue 10
Pg. 1199-1214
(10 2019)
ISSN: 1461-7285 [Electronic] United States |
PMID | 31039654
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)
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Chemical References |
- Glutathione Peroxidase
- Glutathione Reductase
- Glutathione Transferase
- Glutamate-Cysteine Ligase
- Glutathione Synthase
- Glutathione
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Topics |
- Glutamate-Cysteine Ligase
(metabolism)
- Glutathione
(metabolism)
- Glutathione Peroxidase
(metabolism)
- Glutathione Reductase
(metabolism)
- Glutathione Synthase
(metabolism)
- Glutathione Transferase
(metabolism)
- Humans
- Oxidative Stress
- Schizophrenia
(enzymology, metabolism)
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