Abstract | BACKGROUND: METHODS: Passive avoidance memory, locomotor activity and pain perception have been assessed by step-through, open-field and hot-plate instruments, respectively. Anodal and cathodal tDCS were exerted on the left frontal cortex with an intensity of 0.2 milliamps for 20 minutes twice a day in 2 successive days. RESULTS: Our study showed that STZ at doses of 30 and 60 mg/ml/kg caused amnesia, while they did not alter locomotor activity and a higher dose of STZ induced analgesia 14 days after injection. SCH23390 (0.001 mg/mL/kg) and sulpiride (0.1 mg/mL/kg) did not alter memory formation by themselves and amnesia induced by STZ (30 and 60 mg/mL/kg), while SCH23390 restored the analgesia induced by STZ (60 mg/mL/kg). Moreover, left frontal anodal and cathodal tDCS restored memory impairment induced by STZ (30 and 60 mg/mL/kg). Also, SCH23390 and sulpiride could prohibit the anodic stimulating effect on memory impairment induced by a dose of 60 mg/ml/kg, but they did not hinder the effect of the cathodal stimulation on this phenomenon. CONCLUSION: The study showed that D1 and D2 dopamine receptors are involved in the restoration effect of left frontal anodal- but not cathodal- tDCS in STZ-induced amnesia.
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Authors | Afshin Roostaei, Gholamhassan Vaezi, Mohammad Nasehi, Ali Haeri-Rohani, Mohammad-Reza Zarrindast |
Journal | Archives of Iranian medicine
(Arch Iran Med)
Vol. 22
Issue 3
Pg. 144-154
(03 01 2019)
ISSN: 1735-3947 [Electronic] Iran |
PMID | 31029071
(Publication Type: Journal Article)
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Copyright | © 2019 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Chemical References |
- DRD2 protein, rat
- Dopamine Antagonists
- Drd1 protein, rat
- Receptors, Dopamine
- Receptors, Dopamine D1
- Receptors, Dopamine D2
- Streptozocin
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Topics |
- Amnesia
(chemically induced)
- Animals
- Dopamine Antagonists
- Humans
- Male
- Memory
(drug effects)
- Rats
- Rats, Wistar
- Receptors, Dopamine
- Receptors, Dopamine D1
- Receptors, Dopamine D2
- Streptozocin
(administration & dosage)
- Transcranial Direct Current Stimulation
(methods)
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