The clinical utility of phase-based respiratory gated PET imaging based on visual feedback with a head-mounted display system.

Abstract

OBJECTIVE:

We developed a new respiratory-gated positron emission tomography (PET) imaging method (RGV-PET) that phase-based respiratory gated PET imaging (RG-PET) combine with head-mounted display (HMD)-guided "visual feedback." The purpose of this study was to investigate whether RGV-PET is effective at improving the quantitative measurement of tracer uptake in tumors using the phase-based respiratory gating method.

METHODS:

Of the 41 enrolled patients with hepatobiliary or pancreatic cancer, 20 patients underwent RGV-PET and the remaining 21 patients underwent RG-PET. We measured the peak standardized uptake value (SUVpeak) of the primary lesion in each five bins obtained from both RG-PET and RGV-PET. The SUVpeak change rate calculated based on the ungated PET imaging. To evaluate the quantitative variation, the coefficient of variation of the SUVpeak change rate was compared between RG-PET and RGV-PET. In addition, we performed qualitative evaluation using visual score for the incidence of artifacts on four-dimensional-CT.

RESULTS:

The coefficient of variation of the average SUVpeak change rate in RGV-PET was 7.01 ± 4.43, which was significantly lower than the values in RG-PET (10.72 ± 5.74, p < 0.05). A significant improvement in the SUVpeak change rate of RGV-PET was obtained in bins 1 and 2 compared to RG-PET ( p < 0.05). The visual score of RGV-PET was significantly lower than RG-PET ( p < 0.05).

CONCLUSION:

RGV-PET was effective for respiratory stabilization and improved respiratory gating imaging quality.

ADVANCES IN KNOWLEDGE:

The RGV-PET is applicable to various PET/CT respiratory gating imaging and may improve the quantitativeness of PET images.

• Authors: Takuya Mitsumoto, Ryogo Minamimoto, Fumio Sunaoka, Seishi Kishimoto, Kazumasa Inoue, Masahiro Fukushi
• Journal: The British journal of radiology (Br J Radiol) Vol. 92 Issue 1098 Pg. 20180233 (Jun 2019) ISSN: 1748-880X [Electronic] England
• PMID: 31017455 (Publication Type: Comparative Study, Evaluation Study, Journal Article)

Chemical References

• Radiopharmaceuticals
• Fluorodeoxyglucose F18

Topics

• Aged
• Biliary Tract Neoplasms (diagnostic imaging)
• Equipment Design
• Feedback, Sensory
• Female
• Fluorodeoxyglucose F18
• Humans
• Liver Neoplasms (diagnostic imaging)
• Male
• Multimodal Imaging (methods)
• Pancreatic Neoplasms (diagnostic imaging)
• Positron Emission Tomography Computed Tomography (methods, standards)
• Positron-Emission Tomography (methods, standards)
• Radiopharmaceuticals
• Respiratory-Gated Imaging Techniques (methods)
• Retrospective Studies
• Sensitivity and Specificity
• User-Computer Interface