The Role of Host Genetic Polymorphisms in Helicobacter pylori Mediated Disease Outcome.

Abstract

The clinical outcome of infection with the chronic gastric pathogen Helicobacter pylori is not the same for all individuals and also differs in different ethnic groups. Infection occurs in early life (<3 years of age), and while all infected persons mount an immune response and develop gastritis, the majority of individuals are asymptomatic. However, up to 10-15% develop duodenal ulceration, up to 1% develop gastric cancer (GC) and up to 0.1% can develop gastric mucosa-associated lymphoid tissue (MALT) lymphoma. The initial immune response fails to clear infection and H. pylori can persist for decades. H. pylori has been classified as a group one carcinogen by the WHO. Interestingly, development of duodenal ulceration protects against GC. Factors that determine the outcome of infection include the genotype of the infecting strains and the environment. Host genetic polymorphisms have also been identified as factors that play a role in mediating the clinical outcome of infection. Several studies present compelling evidence that polymorphisms in genes involved in the immune response such as pro and anti-inflammatory cytokines and pathogen recognition receptors (PRRs) play a role in modulating disease outcome. However, as the number of studies grows emerging confounding factors are small sample size and lack of appropriate controls, lack of consideration of environmental and bacterial factors and ethnicity of the population. This chapter is a review of current evidence that host genetic polymorphisms play a role in mediating persistent H. pylori infection and the consequences of the subsequent inflammatory response.

• Authors: Marguerite Clyne, Marion Rowland
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 1149 Pg. 151-172 ( 2019) ISSN: 0065-2598 [Print] United States
• PMID: 31016623 (Publication Type: Journal Article, Review)

Topics

• Gastritis (etiology, microbiology)
• Genetic Predisposition to Disease
• Helicobacter Infections (complications, genetics)
• Helicobacter pylori
• Host-Pathogen Interactions
• Humans
• Lymphoma, B-Cell, Marginal Zone (etiology, genetics, microbiology)
• Polymorphism, Genetic
• Stomach Neoplasms (etiology, genetics, microbiology)