Abstract | BACKGROUND AND OBJECTIVES: DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: RESULTS:
Serum albumin levels in the outpatient cohort ranged from 2.4 to 4.9 g/dl, with a median of 3.7 g/dl (interquartile range, 3.5-4.1). Serum albumin had no association with urinary diuretic delivery (r=-0.05; P=0.52), but higher levels weakly correlated with better diuretic efficiency (r=0.17; P=0.02). However, serum albumin inversely correlated with systemic inflammation as assessed by plasma IL-6 (r=-0.35; P<0.001), and controlling for IL-6 eliminated the diuretic efficiency- serum albumin association (r=0.12; P=0.12). In the inpatient cohort, there was no association between serum albumin and urinary diuretic excretion (r=0.15; P=0.32) or diuretic efficiency (r=-0.16; P=0.25). In the outpatient cohort, 39% of patients had microalbuminuria, and 18% had macroalbuminuria. There was no correlation between albuminuria and diuretic efficiency after adjusting for kidney function (r=-0.02; P=0.89). Results were similar in the inpatient cohort. CONCLUSIONS:
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Authors | Antonios Charokopos, Matthew Griffin, Veena S Rao, Lesley Inker, Krishna Sury, Jennifer Asher, Jeffrey Turner, Devin Mahoney, Zachary L Cox, F Perry Wilson, Jeffrey M Testani |
Journal | Clinical journal of the American Society of Nephrology : CJASN
(Clin J Am Soc Nephrol)
Vol. 14
Issue 5
Pg. 712-718
(05 07 2019)
ISSN: 1555-905X [Electronic] United States |
PMID | 31010938
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 by the American Society of Nephrology. |
Chemical References |
- Interleukin-6
- Serum Albumin
- Sodium Potassium Chloride Symporter Inhibitors
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Topics |
- Aged
- Aged, 80 and over
- Albuminuria
(urine)
- Cohort Studies
- Female
- Heart Failure
(drug therapy, metabolism)
- Humans
- Interleukin-6
(blood)
- Male
- Middle Aged
- Serum Albumin
(analysis)
- Sodium Potassium Chloride Symporter Inhibitors
(pharmacology, therapeutic use, urine)
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