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Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics.

Abstract
Natural-product macrolide 10,11-dehydrocurvularin (DCV) was revealed to be a potent irreversible inhibitor of ATP-citrate lyase (ACLY) via classical chemoproteomic profiling, which mechanistically illuminates the anti-cancer mode of action of DCV and its analogues.
AuthorsZhangshuang Deng , Nai-Kei Wong , Zhiyong Guo , Kun Zou , Youli Xiao , Yiqing Zhou
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 55 Issue 29 Pg. 4194-4197 (Apr 04 2019) ISSN: 1364-548X [Electronic] England
PMID30895984 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • dehydrocurvularin
  • Zearalenone
  • ATP Citrate (pro-S)-Lyase
Topics
  • ATP Citrate (pro-S)-Lyase (antagonists & inhibitors, metabolism)
  • Antineoplastic Agents (pharmacology)
  • Cell Proliferation (drug effects)
  • Enzyme Inhibitors (pharmacology)
  • HeLa Cells
  • Humans
  • Proteomics
  • Zearalenone (analogs & derivatives, pharmacology)

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