Abstract | BACKGROUND: OBJECTIVES: MATERIALS AND METHODS: Patch test data from healthcare workers who developed hand dermatitis after wearing rubber gloves and who reacted positively to glove samples and rubber additives were collected from September 2010 to December 2017 in a Belgian hospital. RESULTS: A total of 44 caregivers were included in this study. Patch tests showed that: (a) 84% of the study population reacted positively to carba mix; (b) 86% reacted positively to 1,3- diphenylguanidine; and (c) 13 (30%) reacted positively to thiuram mix. Half of the subjects reacted positively to gloves containing 1,3-diphenylguanidine, whereas none reacted to accelerator-free gloves. CONCLUSION: The most commonly identified allergen was 1,3-diphenylguanidine, far ahead of thiurams, which were previously described as the most sensitizing accelerators. The use of 1,3-diphenylguanidine-free gloves is recommended. No subject reacted to gloves without accelerators, thus confirming their efficiency among accelerator-sensitized patients. We recommend that 1,3-diphenylguanidine be added to the European baseline series.
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Authors | Guillaume Dejonckheere, Anne Herman, Marie Baeck |
Journal | Contact dermatitis
(Contact Dermatitis)
Vol. 81
Issue 3
Pg. 167-173
(Sep 2019)
ISSN: 1600-0536 [Electronic] England |
PMID | 30891769
(Publication Type: Journal Article)
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Copyright | © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Elastomers
- Guanidines
- Thiram
- carbamix
- diphenylguanidine
- Ditiocarb
|
Topics |
- Adult
- Dermatitis, Allergic Contact
(etiology)
- Dermatitis, Occupational
(etiology)
- Ditiocarb
(adverse effects)
- Elastomers
(adverse effects)
- Female
- Gloves, Surgical
(adverse effects)
- Guanidines
(adverse effects)
- Hand Dermatoses
(chemically induced)
- Health Care Sector
- Humans
- Male
- Middle Aged
- Patch Tests
- Thiram
(adverse effects)
- Young Adult
|