Association of single nucleotide polymorphism in hsa-miR-499 and hsa-miR-196a2 with the risk of prostate cancer.

Abstract

BACKGROUND:

Prostate cancer (PCa) is one the most common malignant cancers in men. Micro-RNAs are a group of a noncoding small molecule, which plays critical roles in signalling pathways, metabolism, apoptosis and cancer development. The purpose of this study was to examine the possible association between the hsa-miR-499 (rs3746444) and hsa-miR-196a2 (rs11614913) gene polymorphisms with the risk of PCa.

METHODS:

The case-control investigation was performed on 300 peripheral blood samples, consisting of 150 patients with PCa and 150 healthy men without a family history of cancers. Genetic variations of hsa-miR-499 and hsa-miR-196a2 genes were assessed using the PCR-RFLP method.

RESULTS:

The T/T + TC/CC genotype frequencies showed a significant association between has-mir499 (rs3746444 T>C) gene polymorphism with the risk of PCa (p = 0.027; OR 1.780; 95% CI 1.030-3.113). The genotype frequencies of hsa-miR-196a2 gene did not reveal a statistically significant difference between two groups (p > 0.05).

CONCLUSION:

Our findings supported that hsa-miR-499 gene polymorphism significantly increased susceptibility to PCa and may be considered as a potential prognostic biomarker in PCa patients. The findings suggested that no correlation between hsa-miR-196a2 gene polymorphism and PCa susceptibility in an Iranian population.

• Authors: Ramin Nouri, Saeid Ghorbian
• Journal: International urology and nephrology (Int Urol Nephrol) Vol. 51 Issue 5 Pg. 811-816 (May 2019) ISSN: 1573-2584 [Electronic] Netherlands
• PMID: 30863967 (Publication Type: Journal Article)

Chemical References

• MIRN196 microRNA, human
• MIRN499 microRNA, human
• MicroRNAs

Topics

• Adult
• Aged
• Aged, 80 and over
• Case-Control Studies
• Humans
• Male
• MicroRNAs (genetics)
• Middle Aged
• Polymorphism, Single Nucleotide
• Prostatic Neoplasms (epidemiology, genetics)
• Risk Assessment