The role of lipocalin-2 serum levels in the diagnostics of endometrial cancer.

Abstract

BACKGROUND:

Endometrial cancer is one of the most common tumor of the woman genital organs.

OBJECTIVE:

The goal of this study was to determine the lipocalin-2 levels in patients with endometrial cancer compared to those with normal endometrium or mild endometrial pathologies.

METHODS:

Study included 123 patients with BMI > 21 kg/m2 who were admitted due to abnormal bleeding, in which 52 patients with endometrial cancer. The NGAL, CA125, HE4 serum levels were determined for all patients.

RESULTS:

Significantly lower median NGAL serum levels were found in a group of patients with normal endometrium compared to the endometrial cancer group, p= 0.006. NGAL protein area under ROC curves value as a diagnostic test, differentiating between endometrial cancer and other benign changes endometrium is AUC - 0.81 (p< 0.00001). The NGAL protein had a high sensitivity in all patients included in the analysis: 84% vs. 82% in pre-menopausal patients, and 81% in postmenopausal women with a specificity of 78%, 80% and 87%, respectively. The independent variable for FIGO and model logistic regression proves that NGAL is statistically significant (p= 0.000602), the odds ratio is 3.66. The model for grading shows, that NGAL increase by one ng/ml increases risk chances by 2.32 times in diagnosis with less cancer differentiation.

CONCLUSIONS:

Our preliminary studies demonstrate that lipocalin-2 may be of value in the diagnostics of uterine body cancers.

• Authors: Aneta Cymbaluk-Płoska, Anita Chudecka-Głaz, Ewa Pius-Sadowska, Bogusław Machaliński, Agnieszka Sompolska-Rzechuła, Sebastian Kwiatkowski, Janusz Menkiszak
• Journal: Cancer biomarkers : section A of Disease markers (Cancer Biomark) Vol. 24 Issue 3 Pg. 315-324 ( 2019) ISSN: 1875-8592 [Electronic] Netherlands
• PMID: 30829613 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Biomarkers, Tumor
• LCN2 protein, human
• Lipocalin-2

Topics

• Adult
• Aged
• Biomarkers
• Biomarkers, Tumor
• Diagnosis, Differential
• Endometrial Neoplasms (blood, diagnosis)
• Female
• Humans
• Lipocalin-2 (blood)
• Middle Aged
• Neoplasm Grading
• Neoplasm Staging
• Prognosis
• ROC Curve
• Sensitivity and Specificity