Hyperadrenocorticism Caused by a Pituitary Ganglioglioma in a Dog.

Abstract

An 11-year-old castrated male Chihuahua dog was presented with complaints of polyuria, polydipsia, abdominal enlargement, and alopecia. Hyperadrenocorticism was diagnosed on the basis of clinical signs, blood tests, adrenocorticotropin-stimulation test results, and an elevated serum adrenocorticotropin concentration. Contrast-enhanced magnetic resonance imaging showed that the pituitary gland was enlarged, compatible with a pituitary macroadenoma. Pituitary-dependent hyperadrenocorticism was suspected, and transsphenoidal hypophysectomy was thus performed for complete resection of the tumor. After surgery, the serum adrenocorticotropin concentration normalized and the hyperadrenocorticism resolved. Histological and immunocytochemical analyses revealed a benign tumor composed of mature neuronal cells and glial cells, suggestive of a ganglioglioma with immunolabeling for adrenocorticotropin. Careful analysis of the resected tumor revealed no pituitary adenoma tissue. The clinical and histopathologic findings indicated that the ganglioglioma was directly responsible for the hyperadrenocorticism. This is the first case of hyperadrenocorticism caused by a ganglioglioma in a dog.

• Authors: Hirokazu Ishino, Susumu Takekoshi, Takahiro Teshima, Kazuyuki Uchida, Iwao Sakonju, Yasushi Hara
• Journal: Veterinary pathology (Vet Pathol) Vol. 56 Issue 4 Pg. 609-613 (07 2019) ISSN: 1544-2217 [Electronic] United States
• PMID: 30774022 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenocorticotropic Hormone

Topics

• Adrenocortical Hyperfunction (diagnostic imaging, etiology, pathology, veterinary)
• Adrenocorticotropic Hormone (blood)
• Animals
• Corticotrophs (pathology)
• Dog Diseases (diagnostic imaging, etiology, pathology)
• Dogs
• Ganglioglioma (complications, pathology, veterinary)
• Hypophysectomy (veterinary)
• Magnetic Resonance Imaging (veterinary)
• Male
• Pituitary Diseases (complications, pathology, veterinary)
• Pituitary Gland (diagnostic imaging, pathology)