[Results of a phase II study with the new cytostatic drug carboplatin in combination with 5-fluorouracil in the primary treatment of advanced squamous cell cancers of the head and neck].

Abstract

Chemotherapeutic regimens containing Cisplatin are the most effective in the treatment of squamous cell carcinoma of the head and neck. Because of the high rate of dose-limiting side effects of Cisplatin, Carboplatin, a second generation Cisplatin analog, was tested in a phase II trial with 5-FU on 55 previously untreated patients with advanced carcinoma of the head and neck. The results of the completed study are: 33% CR, 54% PR, 10% NR and 4% PD. Toxic side effects were tolerable myelotoxicity as with Cisplatin/5FU, mild nausea, vomiting and nephrotoxicity. No ototoxicity was seen. Most patients showed better performance status after chemotherapy with increased body weight. These results indicate that Carboplatin/5-FU is more effective and has milder side effects than Cisplatin/5-FU.

• Authors: P Volling, M Schröder, W Rauschning, W Achterrath, E Stennert, G Nagel
• Journal: HNO (HNO) Vol. 36 Issue 11 Pg. 452-5 (Nov 1988) ISSN: 0017-6192 [Print] Germany
• Vernacular Title: Ergebnisse einer Phase II-Studie mit dem neuen Zytostatikum Carboplatin in Kombination mit 5-Fluorouracil zur primären Behandlung fortgeschrittener Plattenepithelkarzinome im Kopf-Halsbereich.
• PMID: 3069815 (Publication Type: English Abstract, Journal Article)

Chemical References

• Organoplatinum Compounds
• Carboplatin
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Carboplatin
• Carcinoma, Squamous Cell (drug therapy, pathology)
• Drug Evaluation
• Female
• Fluorouracil (administration & dosage)
• Head and Neck Neoplasms (drug therapy, pathology)
• Humans
• Male
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Staging
• Organoplatinum Compounds (administration & dosage)