Outcomes from cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal epithelial neoplasms.

Abstract

BACKGROUND:

Appendiceal epithelial neoplasms are rare cancers. Management of peritoneal disease from appendiceal neoplasms has historically been with debulking surgery. In recent decades, the advent of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has become the standard of care. Here, we report our single institution 10-year experience with CRS and HIPEC for appendiceal neoplasms.

METHODS:

This is a retrospective review from 1 January 2008 to 1 June 2017 of all patients undergoing CRS and HIPEC for appendiceal neoplasms. Institutional ethics approval was granted for this project.

RESULTS:

One hundred and seventy-two patients underwent 208 CRSs during this time. Overall, 83.72% of patients had one CRS and HIPEC procedure. Pseudomyxoma peritonei from a perforated appendiceal mucinous neoplasm accounted for 67.9% of cases. The median peritoneal carcinomatosis index (PCI) was 14, with complete cytoreduction achieved in 74.2% of patients. Fifty-four percent of patients had at least one complication, with one (0.5%) peri-operative mortality in our cohort. For the entire cohort, the median overall survival was 104 months and a 5-year survival of 75%. In those having a complete cytoreduction, 5-year survival was 90%, with a median disease free interval of 63 months. PCI and completeness of cytoreduction were independent predictors of overall survival.

CONCLUSION:

Our results demonstrate that CRS and HIPEC for appendiceal neoplasms are safe and effective. Despite carrying some morbidity, it offers patients an excellent disease free and overall survival.

• Authors: Vignesh Narasimhan, Toan Pham, Satish Warrier, A Craig Lynch, Michael Michael, Jeanne Tie, Robert Ramsay, Alexander Heriot
• Journal: ANZ journal of surgery (ANZ J Surg) Vol. 89 Issue 9 Pg. 1035-1040 (09 2019) ISSN: 1445-2197 [Electronic] Australia
• PMID: 30685879 (Publication Type: Journal Article, Review)
• Copyright: © 2019 Royal Australasian College of Surgeons.

Chemical References

• Antibiotics, Antineoplastic
• Mitomycin

Topics

• Antibiotics, Antineoplastic (administration & dosage, therapeutic use)
• Appendiceal Neoplasms (complications, pathology, therapy)
• Australia (epidemiology)
• Chemotherapy, Cancer, Regional Perfusion (methods)
• Cytoreduction Surgical Procedures (adverse effects, methods)
• Female
• Humans
• Hyperthermia, Induced (methods)
• Laparotomy (methods)
• Male
• Middle Aged
• Mitomycin (administration & dosage, therapeutic use)
• Perioperative Period (mortality)
• Peritoneal Neoplasms (pathology)
• Prospective Studies
• Pseudomyxoma Peritonei (surgery)
• Retrospective Studies
• Survival Analysis