A pH-driven ring translocation switch against cancer cells.

Abstract

A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 102 cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.

• Authors: Qian Cheng , Hang Yin , Roselyne Rosas , Didier Gigmes , Olivier Ouari , Ruibing Wang , Anthony Kermagoret , David Bardelang
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 54 Issue 98 Pg. 13825-13828 (Dec 06 2018) ISSN: 1364-548X [Electronic] England
• PMID: 30462104 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Bridged-Ring Compounds
• Imidazoles
• Viologens
• cucurbit(7)uril

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacology)
• Bridged-Ring Compounds (chemistry, pharmacology)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Humans
• Hydrogen-Ion Concentration
• Imidazoles (chemistry, pharmacology)
• Mice
• Neoplasms (drug therapy)
• RAW 264.7 Cells
• Viologens (chemistry, pharmacology)