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Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells.

Abstract
Adenylate cyclase 7 (AC7) has been reported to participate in various biological processes during cancer progression. However, the roles of AC7 in all-trans retinoic acid (ATRA)-induced differentiation of acute promyelocytic leukemia (APL) cells are still unknown. In this study, firstly, our results showed that AC7 affected intracellular cAMP level and influenced ATRA-induced differentiation of APL cells. Secondly, we revealed that miR-192 could directly target AC7 expression and knockdown of miR-192 promoted ATRA-induced APL cell differentiation by regulating AC7 expression. Furthermore, we found that AC7 expression was lower in patients with relapsed APL than that in patients with newly diagnosed APL, while miR-192 expression was relatively higher in patients with relapsed APL. Taken together, our results show that miR-192-mediated AC7 could play important roles in differentiation of APL cells, AC7 and miR-192 might be new biomarkers and therapeutic targets for patients with relapsed APL.
AuthorsBing He, Yanyan Chang, Chao Yang, Zhanglin Zhang, Guiping Xu, Xianqi Feng, Likun Zhuang
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 506 Issue 3 Pg. 543-547 (11 30 2018) ISSN: 1090-2104 [Electronic] United States
PMID30366671 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2018 Elsevier Inc. All rights reserved.
Chemical References
  • MIRN192 microRNA, human
  • MicroRNAs
  • RNA, Messenger
  • Tretinoin
  • Cyclic AMP
  • Adenylyl Cyclases
  • adenylyl cyclase 7
Topics
  • Adenylyl Cyclases (genetics, metabolism)
  • Base Sequence
  • Cell Differentiation (drug effects)
  • Cell Line, Tumor
  • Cyclic AMP (biosynthesis)
  • Down-Regulation (drug effects, genetics)
  • Gene Expression Regulation, Leukemic (drug effects)
  • Gene Knockdown Techniques
  • Humans
  • Leukemia, Promyelocytic, Acute (diagnosis, genetics, pathology)
  • MicroRNAs (genetics, metabolism)
  • RNA, Messenger (genetics, metabolism)
  • Recurrence
  • Tretinoin (pharmacology)
  • Up-Regulation (drug effects)

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