Abstract | CONTEXT: MATERIALS AND METHODS: A 34-year-old female presented with hypocalcaemia (6.0 mg/dL) and hypomagnesaemia (1.1 mg/dL) accompanied by low serum PTH (2.4 pg/mL) as well as urinary calcium and magnesium wasting. She was diagnosed with hypoparathyroidism, which was refractory to standard therapy. She was started on 60 mg prednisone and 150 mg azathioprine treatment daily on suspicion of an autoimmune aetiology. The patient was tested for CaSR antibodies. RESULTS: CONCLUSION: This is the first demonstration of CaSR antibody-mediated hypoparathyroidism responsive to immunosuppressive therapy, adding to the evidence that autoimmune hypoparathyroidism can be, in some cases, reversible and not the result of autoimmune parathyroid destruction.
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Authors | Mina Chamberlin, E Helen Kemp, Anthony P Weetman, Bhupesh Khadka, Edward M Brown |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 90
Issue 1
Pg. 214-221
(01 2019)
ISSN: 1365-2265 [Electronic] England |
PMID | 30358904
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2018 John Wiley & Sons Ltd. |
Chemical References |
- Autoantibodies
- Immunosuppressive Agents
- Receptors, Calcium-Sensing
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Topics |
- Adult
- Autoantibodies
(blood)
- Autoimmune Diseases
(therapy)
- Female
- Humans
- Hypoparathyroidism
(immunology, therapy)
- Immunosuppressive Agents
(therapeutic use)
- Receptors, Calcium-Sensing
(immunology)
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