Abstract |
Endogenous retroviruses are known to affect expression of cellular genes in the vicinity of their integration sites. The endogenous mouse mammary tumor provirus (Mtv-8) previously has been reported to reside on mouse chromosome 6 near the immunoglobulin kappa chain locus. Using pairs of mouse strains on the BALB/c (Mtv-8 positive) and C58 (Mtv-8 negative) backgrounds which are congenic for chromosome 6 genetic markers, we have confirmed the chromosome assignment of this provirus. Moreover, we have analyzed the N1 progeny of a (B6 X C58) X C58 backcross to determine the segregation of the Mtv-8 provirus with respect to polymorphisms in the Igk-VSer and Igk-J loci. The results with congenic and backcross mice together with results of others suggest that Mtv-8 is located approximately 0.52 cM from several closely linked kappa markers on chromosome 6.
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Authors | J N Yang, R T Boyd, P D Gottlieb, J P Dudley |
Journal | Immunogenetics
(Immunogenetics)
Vol. 25
Issue 4
Pg. 222-7
( 1987)
ISSN: 0093-7711 [Print] United States |
PMID | 3032783
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Genetic Markers
- Immunoglobulin kappa-Chains
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Topics |
- Animals
- Chromosome Mapping
- Genes, Viral
- Genetic Markers
- Immunoglobulin kappa-Chains
(genetics)
- Mammary Tumor Virus, Mouse
(genetics)
- Mice
- Mice, Inbred Strains
- Polymorphism, Genetic
- Recombination, Genetic
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