Abstract |
Chronic intestinal inflammation is critical risk factor of colorectal cancer. Triticum aestivum sprouts have been reported to provide a number of health benefits and used as a dietary supplement. In this study, the authors investigated the regulatory effects of T. aestivum sprouts ethanol extract (TAEE) on experimental colorectal carcinogenesis in an azoxymethane (AOM)/ dextran sulfate sodium (DSS)-induced mouse model. Oral administration of TAEE significantly attenuated crypt destruction and tumor formation in AOM/DSS-treated mice. Levels of inflammatory mediators involved in colorectal carcinogenesis, that is, tumor necrosis factor-α, interkeukin (IL)-1β, IL-6, cyclooxygenase-2, and inducible nitric oxide synthase, were lower in the colons of 200 mg/kg TAEE-treated mice than in AOM/DSS controls (p < 0.05). Immunohistochemical staining showed that levels of nuclear factor-kappa B p65 and β- catenin were attenuated by TAEE in the colon tissues of AOM/DSS-treated mice. Furthermore, levels of β- catenin-related genes (cyclin D1 and c-Myc), which are known to contribute to cell cycle regulation, were decreased in the colon tissues of TAEE-treated mice versus AOM/DSS controls (p < 0.01). These results showed TAEE inhibited colon inflammation and neoplasm formation caused by AOM/DSS treatment, suggesting that TAEE could be useful for the prevention and treatment of colitis-associated colon cancer.
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Authors | Hyeon-Hui Ki, Ji-Hyun Lee, Hoon-Yeon Lee, Young-Mi Lee, Dae-Ki Kim |
Journal | Nutrition and cancer
(Nutr Cancer)
2018 Aug-Sep
Vol. 70
Issue 6
Pg. 928-937
ISSN: 1532-7914 [Electronic] United States |
PMID | 30273050
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CTNNB1 protein, mouse
- Inflammation Mediators
- Plant Extracts
- Transcription Factor RelA
- beta Catenin
- Dextran Sulfate
- Azoxymethane
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Topics |
- Animals
- Azoxymethane
- Colonic Neoplasms
(chemically induced, prevention & control)
- Dextran Sulfate
- Inflammation Mediators
(analysis)
- Male
- Mice
- Mice, Inbred BALB C
- Plant Extracts
(therapeutic use)
- Transcription Factor RelA
(analysis)
- Triticum
(chemistry)
- Wnt Signaling Pathway
(drug effects)
- beta Catenin
(analysis, physiology)
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