High-fat diet induced
obesity was associated with more aggressive
prostate cancer. Recent research has demonstrated that
integrin-linked kinase (ILK), β-parvin and downstream
cofilin 1 jointly affected
cancer progression. Meanwhile, these
proteins were also involved in energy metabolism. Therefore, the present study was conducted to investigate the potential function of ILK, β-parvin and
cofilin 1 in the high-fat diet-induced progression of
prostate cancer. Transgenic mice with
prostate cancer were employed, fed with different diets and sacrificed at 20 and 28 weeks.
Tumor differentiation,
extracapsular extension and
metastasis were compared between the groups. Expression levels of ILK, β-parvin and
cofilin 1 in prostate were evaluated by immunohistochemical analysis and determined by an immunoreactivity score. Public databases were applied for analysis and validation. It was detected that high-fat diet feeding promoted
cancer progression in transgenic mice with
prostate cancer, with increased expressions of β-parvin (P=0.038) and
cofilin 1 (P=0.018). Higher expressions of ILK, β-parvin and
cofilin 1 were also associated with poorer
cancer differentiation. Additionally, higher
mRNA levels of CFL1 were correlated with a worse disease-free survival in patients of certain subgroups from The
Cancer Genome Atlas database. Further studies were warranted in discussing the potential roles of ILK, β-parvin and
cofilin 1 in high-fat diet feeding induced progression of
prostate cancer.