A Single-Nucleotide Polymorphism Upstream of the HLA-C Locus Is Associated With an Anti-Hepatitis C Virus-Seronegative State in a High-Risk Exposed Cohort.

Abstract	In this study, we examined the impact of the rs9264942 single-nucleotide polymorphism, previously shown to be associated with human immunodeficiency virus infection status and HLA-C expression, on the hepatitis C virus status in 359 people who inject drugs (PWID). The linkage of rs9264942 alleles to HLA-C antigens assigned to different expression levels was confirmed. Multivariate analysis revealed the age (P = .003) and the rs9264942 genotype (P = .006) to be independent factors for the classification to the PWID groups. Our study showed that the presence of the rs9264942 C/C genotype was associated with persistent seronegativity.
Authors	Christine Thoens, Andreas Heinold, Monika Lindemann, Peter A Horn, Dae-In Chang, Norbert Scherbaum, Joerg Timm, Falko M Heinemann
Journal	The Journal of infectious diseases (J Infect Dis) Vol. 218 Issue 12 Pg. 2016-2019 (11 05 2018) ISSN: 1537-6613 [Electronic] United States
PMID	30102364 (Publication Type: Journal Article)
Chemical References	Antibodies, Viral HLA-C Antigens RNA, Viral
Topics	Adolescent Adult Aged Antibodies, Viral (blood) Cohort Studies Female Genetic Predisposition to Disease Genotype HLA-C Antigens (genetics) Hepacivirus (genetics) Hepatitis C (etiology, genetics, immunology) Humans Male Middle Aged Polymorphism, Single Nucleotide RNA, Viral (isolation & purification) Risk Factors Substance Abuse, Intravenous (complications) Young Adult

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