Etiologies, risk factors, and outcomes of bacterial cholangitis after living donor liver transplantation.

Abstract

The interpretation of bacterial cholangitis after liver transplantation (LT) remains vague, because the presence of bacteria in bile, namely bacteriobilia, does not necessarily indicate an active infection. We investigated the association between post-LT bacterial cholangitis and a variety of short- and long-term outcomes. Two-hundred-seventy-four primary adult-to-adult living donor LT recipients from 2008 to 2016 were divided into three groups according the presence or absence of bacteriobilia and clinical symptoms: (1) no bacteriobilia (N group), (2) asymptomatic bacteriobilia (B group), and (3) cholangitis (C group). The number of patients was by group: N, 161; B, 64; and C, 49. Donor age ≥ 45 years (p = 0.012), choledochojejunostomy (p < 0.001), and post-LT portal hypertension (p = 0.023) were independent risk factors for developing cholangitis. Survival analysis revealed that the C group had significantly worse short- and long-term graft survival. The C group was associated with an increased incidence of early graft loss (EGL) (p < 0.001). While the frequency of readmission for recurrent cholangitis was significantly higher in both the B and C groups (p < 0.001), late graft loss (LGL) due to chronic cholangitis was only commonly observed in the C group (p = 0.002). Post-LT cholangitis could result in not only EGL but also chronic cholangitis and associated LGL.

• Authors: Siyuan Yao, Shintaro Yagi, Miki Nagao, Ryuji Uozumi, Taku Iida, Sena Iwamura, Yosuke Miyachi, Hisaya Shirai, Atsushi Kobayashi, Shinya Okumura, Yuhei Hamaguchi, Yuuki Masano, Toshimi Kaido, Hideaki Okajima, Shinji Uemoto
• Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 37 Issue 10 Pg. 1973-1982 (Oct 2018) ISSN: 1435-4373 [Electronic] Germany
• PMID: 30039291 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents

Topics

• Aged
• Anti-Bacterial Agents (therapeutic use)
• Antibiotic Prophylaxis
• Bacteremia (etiology, mortality)
• Bacterial Infections (drug therapy, etiology, microbiology, mortality)
• Cholangitis (drug therapy, etiology, microbiology, mortality)
• Female
• Humans
• Kaplan-Meier Estimate
• Liver Transplantation (adverse effects, mortality)
• Living Donors
• Male
• Middle Aged
• Postoperative Complications (etiology, microbiology)
• Retrospective Studies
• Risk Factors
• Treatment Outcome