The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas.

Abstract

Different microRNAs are dysregulated in ovarian cancer where some of them have proved to be valid biomarkers. miRNA profiling analyses have shown that the different histotypes of ovarian carcinoma display differential expression of specific miRNAs. In the present study, we used miRNA-sequencing and Real-Time qPCR to detect the expression levels of miRNAs belonging to the miRNA-192/215 family, namely miR-192, miR-194, and miR-215, in different types of ovarian neoplasia, finding that miR-192, miR-194, and miR-215 were upregulated in ovarian carcinomas of the mucinous subtype, but downregulated in other types of carcinoma and in sex cord-stromal tumors. The expression of the said miRNAs was 6-fold higher in mucinous tumors compared to the other histotypes making them candidates for a possible role as diagnostic biomarkers.

• Authors: Antonio Agostini, Marta Brunetti, Ben Davidson, Claes G Tropé, Ane Gerda Z Eriksson, Sverre Heim, Ioannis Panagopoulos, Francesca Micci
• Journal: Scientific reports (Sci Rep) Vol. 8 Issue 1 Pg. 11069 (07 23 2018) ISSN: 2045-2322 [Electronic] England
• PMID: 30038317 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• MIRN192 microRNA, human
• MIRN194 microRNA, human
• MIRN215 microRNA, human
• MicroRNAs

Topics

• Adenocarcinoma, Mucinous (genetics)
• Female
• Gene Expression Profiling
• Gene Expression Regulation, Neoplastic (genetics)
• Humans
• MicroRNAs (genetics)
• Ovarian Neoplasms (genetics)